Liposomes Modification Services of Creative Biolabs Improves Liposomal Delivery Performance
New York, USA – March 21, 2022 – As a drug delivery system, liposomes boast several advantages including biocompatibility, capacity for self-assembly, ability to carry large drug payloads, and a wide range of physicochemical and biophysical properties that can be modified to control their biological characteristics.
However, despite the success of liposomal formulations in vivo, their translation into the clinic has progressed incrementally. As far as conventional liposomes are concerned, there are some unresolved problems in their applications: low targeting, low stability in vivo, easy to be destroyed by various hydrolases or removed from circulation by the reticuloendothelial system (RES).
In order to solve these problems, Creative Biolabs offers functional liposome development services to make up for their shortcomings or to enhance certain functional advantages by introducing functional materials to increase the application potential. According to their composition, liposomes provided by Creative Biolabs can be divided into conventional liposomes, long-circulating liposomes, stimulating-responsive liposomes, immunoliposomes, and so on.
Conventional Liposome Development
Conventional liposomes are a family of vesicle structures based on a lipid bilayer surrounding aqueous compartments, which can be composed of cationic, anionic or neutral lipids and cholesterol. With over ten years of experience in this field, Creative Biolabs can provide distinctive liposomal formulations and products with no cross-contamination by rational design and customized optimization to improve drug delivery efficiency.
Long Circulating Liposomes Development
Long circulating liposome is one of the liposome modified with some polymers, which can make the liposome stay in the blood longer. The stability, clearance and biodistribution of liposomes in blood depend on its composition, size and charge. Creative Biolabs can find the best combination of formula factors through less experiments, and obtain liposomes with expected performance, and provide a variety of characterization and analysis services in the development of liposome formulation agents to optimize the performance of the preparation, including visual appearance, size distribution, stability, Zeta potential, lamellarity, entrapment efficiency, and release rate.
Stimuli-Responsive Liposomes Development
The combination of external or internal stimulation with stimuli-responsive liposomes is an effective way to improve the therapeutic effect of liposomal drug delivery system and reduce adverse reactions. The precise design and control of the structure of stimuli-responsive materials and the combination with functional materials are expected to create new methods to control biological functions, and to prepare highly effective liposomes which can selectively release bioactive molecules. Relying on a professional team of scientists, Creative Biolabs provides a variety of stimuli-responsive liposome preparation and characterization analysis services, including: temperature-responsive liposomes, pH-responsive liposomes, enzyme-responsive liposomes, redox-responsive liposomes, and light-responsive liposomes.
Antibodies can be covalently and non-covalently attached to liposomes to form immunoliposomes, which combine antibody-mediated tumor recognition and liposome delivery, aiming at target cell internalization and intracellular drug release. Immunoliposomes provide a complementary and advantageous drug delivery strategy for antibody drug conjugates in many cases. In the development of immunoliposomes, Creative Biolabs optimizes every step as much as possible, including antibody production, coupling, liposome formulation and drug loading, in order to meet the needs of different clients.
More information about liposome formulation development can be found at https://www.creative-biolabs.com/lipid-based-delivery.
About Creative Biolabs
Based on the accumulation of the expertise and technology in the field of liposomes, Creative Biolabs offers featured services for liposomal formulation development which includes objective evaluation, preparation method selection, drug release control, and almost every detailed section only to meet every client’s needs.
Media Contact
Company Name: Creative Biolabs
Contact Person: Candy Swift
Email: Send Email
Phone: 1-631-830-6441
Country: United States
Website: https://www.creative-biolabs.com/lipid-based-delivery
