Bundelkhand Online Journal

Influenza Pipeline Insight, Clinical Trial Analysis, and NDA Approvals | 120+ Companies and 120+ Drugs

 Breaking News
  • No posts were found

Influenza Pipeline Insight, Clinical Trial Analysis, and NDA Approvals | 120+ Companies and 120+ Drugs

January 23
18:40 2023
Influenza Pipeline Insight, Clinical Trial Analysis, and NDA Approvals | 120+ Companies and 120+ Drugs

DelveInsight’s, “Influenza Pipeline Insight, 2023,” report provides comprehensive insights about 120+ companies and 120+ pipeline drugs in the Influenza pipeline landscape. It covers the Influenza pipeline drug profiles, including Influenza clinical trials and nonclinical stage products. It also covers the Influenza pipeline therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

 

In the Influenza Pipeline Insight Report, a detailed description of the drug is given which includes mechanism of action of the drug, Influenza clinical trial studies, Influenza NDA approvals (if any), and product development activities comprising the technology, Influenza collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

 

Key takeaways from the Influenza Pipeline Insight Report

  • DelveInsight’s influenza pipeline report depicts a robust space with 120+ active players working to develop 120+ pipeline therapies for influenza treatment.
  • The Leading influenza Companies such as Moderna, SAB Biotherapeutics, ENA Respiratory Pty Ltd, Codagenix, AlloVir, Osivax, CureVac AG, GlaxoSmithKline, Cocrystal Pharma Inc, Viriom, Emergent BioSolutions, Pfizer, Jiangxi Qingfeng Pharmaceutical Co. Ltd., Guangdong Raynovent Biotech Co., Ltd, FluGen Inc, BlueWillow Biologics, AVM Biotechnology LLC, Ansun Biopharma, Inc., Guangzhou Henovcom Bioscience, Sunshine Lake Pharma Co., Ltd., Emergex Vaccines, Vir Biotechnology, CSL Limited, Novavax, Mitsubishi Chemical Group Corporation, Poolbeg Pharma, MYMETICS, CELLTRION INC., Avalia Immunotherapies, Meiji Holdings Co., Ltd., Clover Biopharmaceuticals, Airway Therapeutics, Inc., PrEP Biopharm, Cidara Therapeutics, Inc., Medicago, Sanofi, Translate Bio, Arcturus Therapeutics, Inc., BiondVax Pharmaceuticals, Adagio Therapeutics, Virpax Pharmaceuticals, Blue Water Vaccines, SINOVAC, PDS Biotechnology, Pneumagen, Abivax, Seqirus, ExpreS2ion Biotechnologies, Vivaldi Biosciences, Ethris, GC Biopharma, AIM ImmunoTech, Eyam Vaccines And Immunotherapeutics, SyneuRx, and others.
  • Promising Influenza pipeline therapies include mRNA-1010, SAB-176, INNA-051, CODA-VAX H1N1, DAS181, ALVR106, OVX836, VIR-2482, POLB 001, CD388, CT-P27, KD-404, AVA2300, CVSQIV, GSK3206641A, UniFlu, CC-42344, AV5080, mRNA-1073, UFluA, PF-07852352, GP681, ZSP1273, Sing2016, BW-1014, AVM0703, DAS181, HNC042, HEC116094, Adjuvanted Cell Culture Influenza Vaccine (aQIVc), NanoFlu, MT-8972, MT-7529, MT-2654, PrEP-001,GSK4382276A, mRNA Influenza Vaccine, LUNAR-FLU, M–001, Adintrevimab, PDS0202, Neumifil, Influenza vaccine, ETH47, GC3114A,  and others.
  • The Influenza Companies and academics that are working to assess challenges and seek opportunities that could influence Influenza R&D. The Influenza pipeline therapies under development are focused on novel approaches to treat/improve the disease condition.

 

To explore more information on the latest breakthroughs in the Influenza Pipeline treatment landscape of the report, click here @ Influenza Pipeline Outlook

 

Recent Developmental Activities in the Influenza Treatment Landscape

  • In July 2022, Emergex Vaccines Holding Limited through the development of fully synthetic CD8+ T cell Adaptive Vaccines announced the manufacture of its universal/pandemic influenza vaccine, ready for Phase I clinical trials.
  • CureVac has dosed the first participant in a Phase I study of the modified influenza vaccine candidate FLU SV mRNA, developed in collaboration with GSK. The study follows the start of a Phase I study in February 2022 to evaluate an unmodified, multivalent influenza vaccine candidate, CVSQIV, at clinical sites in Panama. Data from both studies are expected to be reported as a combined data set.
  • In June 2022, Moderna, Inc. announced the first participants have been dosed in a Phase III study of the Company’s seasonal influenza vaccine candidate (mRNA-1010). The trial is expected to enroll approximately 6,000 adults in Southern Hemisphere countries. This Phase III randomized, observer-blind study is designed to evaluate the safety and immunological non-inferiority of mRNA-1010 to a licensed seasonal influenza vaccine in adults 18 years and older.
  • In April 2022, Novavax, Inc. announced initial results from the Phase I/II clinical trial of its COVID-Influenza Combination Vaccine (CIC). The CIC combines Novavax’ COVID-19 vaccine, NVX-CoV2373, and its quadrivalent influenza vaccine candidate. The CIC trial demonstrated that formulating the combination vaccine is feasible, well-tolerated and immunogenic.
  • In April 2022, Osivax, announced the Phase IIa results for its broad-spectrum influenza vaccine candidate, OVX836, have been published under the title “Randomized, Double-Blind, Reference-Controlled, Phase IIa Study Evaluating the Immunogenicity and Safety of OVX836, A Nucleoprotein-Based Influenza Vaccine” in the journal Frontiers in Immunology. Developed using Osivax’ proprietary self-assembling nanoparticle technology, OVX836 targets an internal nucleoprotein (NP), a highly conserved antigen that is less susceptible to the constant mutations of surface antigens of the influenza virus.
  • BioNTech is collaborating with Pfizer to develop an influenza vaccine based on BioNTech’s suite of mRNA platforms. In July 2022, data were reported from the Phase II expansion study of BNT161 in subjects 65 years of age and older showing first evidence of substantial induction of strain specific CD4+ and CD8+ responses. The GMFR was higher compared to the control quadrivalent influenza vaccine for both CD4+ and CD8+ strain specific T cell responses. Based on these encouraging T cell responses and observed seroconversion, a Phase III study of the quadrivalent modified mRNA influenza vaccine is planned to initiate in the second half of 2022.
  • In May 2022, Blue Water Vaccines announced a collaboration with the multidisciplinary Center for R&D in Immunobiologics, an initiative of Instituto Butantan , for the development of BWV’s universal influenza candidate, BWV-101, in Brazil. Butantan is the largest flu vaccine manufacturer in the Southern Hemisphere, with 100% of influenza vaccine doses used by the Brazilian Ministry of Health manufactured at Butantan.

 

Influenza Overview

Influenza, one of the most common infectious diseases, is a highly contagious airborne disease that occurs in seasonal epidemics and manifests as an acute febrile illness with variable degrees of systemic symptoms, ranging from mild fatigue to respiratory failure and death. Influenza causes significant loss of workdays, human suffering, and mortality. The CDC documented that seasonal influenza was responsible for 24,000 to 62,000 deaths during the 2019-2020 season. Information used to generate influenza in-season burden estimates were too low during the 2020-2021 season to provide an estimate. Mortality was highest in infants and elderly persons. Influenza traditionally has been diagnosed on the basis of clinical criteria, but rapid diagnostic tests, which have a high degree of specificity but only moderate sensitivity, are becoming more widely used.

 

Request a sample and discover the recent advances in Influenza Ongoing Clinical Trial Analysis and Medications, click here @ Influenza Treatment Landscape

 

Influenza Emerging Drugs Profile

 

mRNA-1010: Moderna

mRNA-1010 is a vaccine candidate that encodes for hemagglutinin (HA) glycoproteins of the four influenza strains recommended by the World Health Organization (WHO) for the prevention of influenza, including influenza A/H1N1, A/H3N2, and influenza B/Yamagata- and B/Victoria-lineages. HA is a major influenza surface glycoprotein that is considered an important target to generate broad protection against influenza and is the primary target of currently available influenza vaccines. Currently, it is in Phase III stage of clinical trial evaluation to treat patients suffering from Seasonal Influenza.

 

SAB-176: SAB Biotherapeutics

SAB-176 is a quadrivalent broadly neutralizing fully-human polyclonal antibody therapeutic candidate that leverages the human biological immune response in development for the treatment of hospitalized patients with severe seasonal influenza. The novel specifically targeted therapeutic generated from the company’s proprietary technology, the DiversitAb™ platform, is designed to specifically bind to Type A and Type B influenza viruses. Pre-clinical data suggests that SAB-176 offers potentially broad protection against diverse influenza strains. A highly-potent, polyclonal antibody therapy for severe seasonal influenza, could potentially treat severely ill patients and provide protective antibodies for high-risk populations, such as the elderly and immune compromised.

 

INNA-051: ENA Respiratory Pty Ltd

INNA-051 is a broad-spectrum antiviral immunomodulatory nasal spray under clinical development for pre- and post-exposure prophylaxis of respiratory viral infections in populations at risk of severe complications. Based on its mechanism of action and intended route of administration, INNA-051 has the potential to address several viral respiratory pathogens across multiple patient populations with a variety of co-morbid conditions. INNA-051 antiviral efficacy is currently evaluated in a Phase 2a influenza-challenge conducted in healthy volunteers.

 

CODA-VAX H1N1: Codagenix

Codagenix has utilized a design platform to construct a live-attenuated, universal flu vaccine, CodaVax™-H1N1. The vaccine enables presentation of conserved antigens of the wild-type virus, demonstrating universal potential in primate models and thus the potential to provide multi-season protection when developed into its final quadrivalent formulation. Currently, it is being evaluated in Phase I stage of clinical trial evaluation to treat Influenza virus infections.

 

ALVR106: AlloVir

ALVR106 is an allogeneic, off-the-shelf, multi-virus specific VST therapy candidate designed to target diseases caused by the respiratory syncytial virus (RSV), influenza, parainfluenza virus (PIV), and human metapneumovirus (hMPV). In vitro data demonstrates that ALVR106 reactive cells have antiviral activity against each of the targeted viruses with minimal or no activity against non-virus-infected cells. This preclinical data supports the potential for antiviral benefit and safety of ALVR106 when administered to patients.

 

Influenza Pipeline Therapeutic Assessment

There are approx. 120+ key companies which are developing the therapies for Influenza. The companies which have their Influenza drug candidates in the most advanced stage, i.e. phase III include, Moderna.

 

For further information, refer to the detailed Influenza Unmet Needs, Influenza Market Drivers, and Market Barriers, click here for Influenza Ongoing Clinical Trial Analysis

 

Scope of the Influenza Pipeline Report

 

  • Coverage: Global
  • Key Influenza Companies: Moderna, SAB Biotherapeutics, ENA Respiratory Pty Ltd, Codagenix, AlloVir, Osivax, CureVac AG, GlaxoSmithKline, Cocrystal Pharma Inc, Viriom, Emergent BioSolutions, Pfizer, Jiangxi Qingfeng Pharmaceutical Co. Ltd., Guangdong Raynovent Biotech Co., Ltd, FluGen Inc, BlueWillow Biologics, AVM Biotechnology LLC, Ansun Biopharma, Inc., Guangzhou Henovcom Bioscience, Sunshine Lake Pharma Co., Ltd., Emergex Vaccines, Vir Biotechnology, CSL Limited, Novavax, Mitsubishi Chemical Group Corporation, Poolbeg Pharma, MYMETICS, CELLTRION INC., Avalia Immunotherapies, Meiji Holdings Co., Ltd., Clover Biopharmaceuticals, Airway Therapeutics, Inc., PrEP Biopharm, Cidara Therapeutics, Inc., Medicago, Sanofi, Translate Bio, Arcturus Therapeutics, Inc., BiondVax Pharmaceuticals, Adagio Therapeutics, Virpax Pharmaceuticals, Blue Water Vaccines, SINOVAC, PDS Biotechnology, Pneumagen, Abivax, Seqirus, ExpreS2ion Biotechnologies, Vivaldi Biosciences, Ethris, GC Biopharma, AIM ImmunoTech, Eyam Vaccines And Immunotherapeutics, SyneuRx, and others
  • Key Influenza Pipeline Therapies: mRNA-1010, SAB-176, INNA-051, CODA-VAX H1N1, DAS181, ALVR106, OVX836, VIR-2482, POLB 001, CD388, CT-P27, KD-404, AVA2300, CVSQIV, GSK3206641A, UniFlu, CC-42344, AV5080, mRNA-1073, UFluA, PF-07852352, GP681, ZSP1273, Sing2016, BW-1014, AVM0703, DAS181, HNC042, HEC116094, Adjuvanted Cell Culture Influenza Vaccine (aQIVc), NanoFlu, MT-8972, MT-7529, MT-2654, PrEP-001,GSK4382276A, mRNA Influenza Vaccine, LUNAR-FLU, M–001, Adintrevimab, PDS0202, Neumifil, Influenza vaccine, ETH47, GC3114A, and others.
  • Influenza Pipeline Segmentation: Phases, Product Type, Molecule Type, Route of administration, Mechanism of action

 

Dive deep into rich insights for drugs for Influenza Market Drivers and Influenza Market Barriers, click here @ Influenza Unmet Needs and Analyst Views

 

Table of Content

  1. Introduction
  2. Influenza Executive Summary
  3. Influenza Overview
  4. Influenza Pipeline Therapeutics
  5. Influenza Pipeline Therapeutic Assessment
  6. Influenza – DelveInsight’s Analytical Perspective
  7. Late Stage Products (Phase III)
  8. mRNA-1010: Moderna
  9. Drug profiles in the detailed report…..
  10. Mid Stage Products (Phase II)
  11. INNA-051: ENA Respiratory Pty Ltd
  12. Drug profiles in the detailed report…..
  13. Early Stage Products (Phase I)
  14. CODA-VAX H1N1: Codagenix
  15. Drug profiles in the detailed report…..
  16. Preclinical and Discovery Stage Products
  17. Drug name: Company name
  18. Drug profiles in the detailed report…..
  19. Inactive Products
  20. Influenza Key Companies
  21. Influenza Key Products
  22. Influenza- Unmet Needs
  23. Influenza- Market Drivers and Barriers
  24. Influenza- Future Perspectives and Conclusion
  25. Influenza Analyst Views
  26. Influenza Key Companies
  27. Appendix

 

Got Queries? Find out the related information on Influenza Mergers and acquisitions, Influenza licensing activities @ Influenza Emerging Drugs, and Recent Trends

 

About Us

DelveInsight is a Business Consulting and Market research company, providing expert business solutions for the healthcare domain and offering quintessential advisory services in the areas of R&D, Strategy Formulation, Operations, Competitive Intelligence, Competitive Landscaping, and Mergers & Acquisitions.

Media Contact
Company Name: DelveInsight Business Research LLP
Contact Person: Yash Bhardwaj
Email: Send Email
Phone: 9193216187
Address:304 S. Jones Blvd #2432
City: Las Vegas
State: NV
Country: United States
Website: https://www.delveinsight.com/consulting/due-diligence-services